The extent of the effect observed can be seen in the research findings if, for example, four of 10 treated women on simvastatin cited worsened energy or exertional fatigue; two in 10 cited worsening in both, or rated either one as “much worse”; or if one in 10 study participants rated energy and exertional fatigue as “much worse.”
“Energy is central to quality of life. It also predicts interest in activity,” said Prof Golomb.
“Exertional fatigue not only predicts actual participation in exercise, but both lower energy and greater exertional fatigue may signal triggering of mechanisms by which statins may adversely affect cell health.”
In light of the findings, the researchers stated that decreases in energy, and increases in exertional fatigue on statins have important implications which should be taken into account in risk-benefit determinations for statins.
