Higher risks were observed for breast cancer and obesity-related cancers.
The authors wrote: “Our findings do not support the use of artificial sweetener as safe alternatives for sugar in foods or beverages and provide important and novel controversies about their potential adverse health effects.
“While these results need to be replicated in other large-scale cohorts and underlying mechanisms clarified by experimental studies, they provide important and novel insights for the ongoing reevaluation of food additive sweeteners by the European Food Author and other health agencies globally.”
When broken down in the gut, sweeteners may disrupt processes that are vital for neutralising harmful toxins from bacteria that live there, according to previous research.