Researchers considered reasons for the health benefits of coffee.
The paper adds: “The most often studied compound in coffee is caffeine, a methylxanthine alkaloid and an adenosine receptor antagonist that significantly alters kidney function by rapid-acting mechanisms, including modification of the renin-angiotensin-aldosterone system, baseline renal plasma flow, hemodynamics, and natriuresis.
“Caffeine also inhibits sodium reabsorption in the proximal and distal tubules of the kidney, thus increasing solute and free water excretion, and has been postulated to fully inhibit the local tubule-glomerular feedback response to increase distal sodium delivery.
“Other less-studied bioactive compounds in coffee including chlorogenic acids, chlorogenic acid lactones, p-coumaric acid, nicotinic acid, theobromine, and trigonelline must also be considered as potential contributors to coffee’s cardiorenal protective effects, as many of these polyphenol compounds are potent plant-based antioxidants that have been found to improve generalised inflammation and oxidative stress,12 key factors in the development of AKI.”
